Identification and Characterization of PDE8 Inhibitors Using a Fission Yeast Based High-throughput Screening Platform
Thesis advisor: Charles S. Hoffman === In this thesis, I describe the development of a screening platform for detecting PDE8A inhibitors using the cAMP-dependent glucose sensing pathway of the fission yeast Schizosaccharomyces pombe, which led us to discover several PDE8A selective inhibitors. In th...
| Main Author: | |
|---|---|
| Format: | Others |
| Language: | English |
| Published: |
Boston College
2011
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/2345/3051 |