Design, synthesis and pharmacological evaluation of original nitrobenzenesulfonylureas and sulfonylcyanoguanidines as thromboxane A2 receptor antagonists/Conception, synthèse et évaluation pharmacologique de nitrobenzènesulfonylurées et sulfonylcyanoguanidines en tant qu'antagonistes des récepteurs au thromboxane A2
Thromboxane A2 (TXA2) is an important mediator metabolized from arachidonic acid through the cyclooxygenase pathway, mainly in platelets and macrophages. It is a potent inducer of platelet aggregation and smooth muscle contraction. Its overproduction has been detected in pathologies such as stroke,...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Others |
| Published: |
Universite de Liege
2007
|
| Subjects: | |
| Online Access: | http://bictel.ulg.ac.be/ETD-db/collection/available/ULgetd-10092007-173228/ |