Design, synthesis and pharmacological evaluation of original nitrobenzenesulfonylureas and sulfonylcyanoguanidines as thromboxane A2 receptor antagonists/Conception, synthèse et évaluation pharmacologique de nitrobenzènesulfonylurées et sulfonylcyanoguanidines en tant qu'antagonistes des récepteurs au thromboxane A2

Design, synthesis and pharmacological evaluation of original nitrobenzenesulfonylureas and sulfonylcyanoguanidines as thromboxane A2 receptor antagonists/Conception, synthèse et évaluation pharmacologique de nitrobenzènesulfonylurées et sulfonylcyanoguanidines en tant qu'antagonistes des récepteurs au thromboxane A2

Thromboxane A2 (TXA2) is an important mediator metabolized from arachidonic acid through the cyclooxygenase pathway, mainly in platelets and macrophages. It is a potent inducer of platelet aggregation and smooth muscle contraction. Its overproduction has been detected in pathologies such as stroke,...

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Bibliographic Details
Main Author: Hanson, Julien
Other Authors: Offermanns, Stephan
Format: Others
Published: Universite de Liege 2007
Subjects:
structure-activity relationship/relations structure-activite
thromboxane
TP receptor antagonist/Antagoniste TP
GPCR/RCPG
Cardiovascular diseases/Maladies cardiovasculaires
platelet aggregation/agregation plaquettaire
medicinal chemistry/chimie pharmaceutique
drug design and synthesis/conception et synthese de medicament
Online Access:http://bictel.ulg.ac.be/ETD-db/collection/available/ULgetd-10092007-173228/

Internet

http://bictel.ulg.ac.be/ETD-db/collection/available/ULgetd-10092007-173228/

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