Investigation into the Effects of PEGylation on the Thermodynamic Stability of the WW Domain
The covalent attachment of poly(ethylene glycol) (PEG) to a protein surface (known as PEGylation), has been demonstrated to increase the serum half-life of therapeutic proteins by reducing kidney clearance and immunogenicity and by protecting against proteolysis. Theses beneficial effects could be f...
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BYU ScholarsArchive
2013
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| Online Access: | https://scholarsarchive.byu.edu/etd/4280 https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=5279&context=etd |