Susceptibility of Apoptotic Cells to Hydrolysis by sPLA2: Molecular Basis and Mechanisms Defined

Secretory phospholipase A2 hydrolyzes phospholipids at a lipid-water interface, resulting in pro-inflammatory products being released from cell membranes. Healthy cells are resistant to cleavage by this enzyme, but apoptotic cells become susceptible to its activity. Only bilayers with certain charac...

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Bibliographic Details
Main Author: Gibbons, Elizabeth
Format: Others
Published: BYU ScholarsArchive 2013
Subjects:
Online Access:https://scholarsarchive.byu.edu/etd/3690
https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=4689&context=etd