Strategic use of nickel(0)-catalyzed enyne-epoxide reductive coupling toward the synthesis of (−)-cyatha-3,12-diene

Strategic use of nickel(0)-catalyzed enyne-epoxide reductive coupling toward the synthesis of (−)-cyatha-3,12-diene

Various situations are explored in which the nickel(0)-catalyzed enyne-epoxide reductive coupling was utilized to access key intermediates toward the total synthesis of (−)-cyatha-3,12-diene (1). Enantioenriched 3,5-dien-1-ols with a variety of functionality were obtained in a straightforward manner...

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Bibliographic Details
Main Authors: Sparling, Brian A. (Contributor), Simpson, Graham L. (Contributor), Jamison, Timothy F. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-10-29T17:49:40Z.
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Summary:Various situations are explored in which the nickel(0)-catalyzed enyne-epoxide reductive coupling was utilized to access key intermediates toward the total synthesis of (−)-cyatha-3,12-diene (1). Enantioenriched 3,5-dien-1-ols with a variety of functionality were obtained in a straightforward manner from easily accessible 1,3-enynes and terminal epoxides.
National Institute of General Medical Sciences (U.S.) (GM-063755)
Massachusetts Institute of Technology. Undergraduate Research Opportunities Program

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