A versatile reporter system for CRISPR-mediated chromosomal rearrangements

A versatile reporter system for CRISPR-mediated chromosomal rearrangements

Although chromosomal deletions and inversions are important in cancer, conventional methods for detecting DNA rearrangements require laborious indirect assays. Here we develop fluorescent reporters to rapidly quantify CRISPR/Cas9-mediated deletions and inversions. We find that inversion depends on t...

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Main Authors: Li, Yingxiang (Author), Mou, Haiwei (Author), Colpan, Cansu (Author), Bizhanova, Aizhan (Author), Akama-Garren, Elliot (Contributor), Joshi, Nik (Contributor), Feldser, David M. (Author), Yin, Hao (Contributor), Weng, Zhiping (Author), Xue, Wen (Author), Park, Angela I. (Author), Hendrickson, Eric A. (Author), Anderson, Daniel Griffith (Contributor), Jacks, Tyler E (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Jacks, Tyler E. (Contributor)
Format: Article
Language:English
Published: BioMed Central, 2015-06-29T18:06:07Z.
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