Potential function for the Huntingtin protein as a scaffold for selective autophagy

Potential function for the Huntingtin protein as a scaffold for selective autophagy

Although dominant gain-of-function triplet repeat expansions in the Huntingtin (HTT) gene are the underlying cause of Huntington disease (HD), understanding the normal functions of nonmutant HTT protein has remained a challenge. We report here findings that suggest that HTT plays a significant role...

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Main Authors: Ochaba, Joseph (Author), Csikos, George (Author), Zheng, Shuqiu (Author), Margulis, Julia (Author), Salazar, Lisa (Author), Mao, Kai (Author), Lau, Alice L. (Author), Yeung, Sylvia Y. (Author), Humbert, Sandrine (Author), Klionsky, Daniel J. (Author), Finkbeiner, Steven (Author), Zeitlin, Scott O. (Author), Marsh, J. Lawrence (Author), Thompson, Leslie M. (Author), Steffan, Joan S. (Author), Lukacsovich, Tamas (Author), Saudou, Frederic (Author), Housman, David E (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Housman, David E. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2015-06-09T17:20:42Z.
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