Cells change their sensitivity to an EGF morphogen gradient to control EGF-induced gene expression

Cells change their sensitivity to an EGF morphogen gradient to control EGF-induced gene expression

How cells in developing organisms interpret the quantitative information contained in morphogen gradients is an open question. Here we address this question using a novel integrative approach that combines quantitative measurements of morphogen-induced gene expression at single-mRNA resolution with...

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Bibliographic Details
Main Authors: Kienle, Simone (Author), Huelsz-Prince, Guizela (Author), Barkoulas, Michalis (Author), van Oudenaarden, Alexander (Contributor), Van Zon, Jeroen Sebastiaan (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), van Zon, Jeroen Sebastiaan (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2015-06-08T14:28:26Z.
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