Nitric oxide and TNF-α trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice

Nitric oxide and TNF-α trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice

Recombinase-activating gene-2-deficient (Rag2[superscript −/−]) mice lacking functional lymphocytes provide a useful model of chronic inflammatory bowel disease-emulating events in human colon cancer. Infection of Rag2[superscript −/−] mice with Helicobacter hepaticus led to accumulation of macropha...

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Bibliographic Details
Main Authors: Rao, V. P. (Contributor), Poutahidis, T. (Contributor), Rogers, A. B. (Contributor), Taylor, C. L. (Contributor), Jackson, E. A. (Contributor), Lee, C. W. (Contributor), Schauer, D. B. (Contributor), Erdman, Susan E. (Contributor), Ge, Zhongming (Contributor), Wogan, Gerald N. (Contributor), Tannenbaum, Steven Robert (Contributor), Fox, James G. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Division of Comparative Medicine (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2015-05-08T15:30:45Z.
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