CHD8 Regulates Neurodevelopmental Pathways Associated with Autism Spectrum Disorder in Neural Progenitors

CHD8 Regulates Neurodevelopmental Pathways Associated with Autism Spectrum Disorder in Neural Progenitors

Truncating mutations of chromodomain helicase DNA-binding protein 8 (CHD8), and of many other genes with diverse functions, are strong-effect risk factors for autism spectrum disorder (ASD), suggesting multiple mechanisms of pathogenesis. We explored the transcriptional networks that CHD8 regulates...

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Main Authors: Sugathan, Aarathi (Author), Biagioli, Marta (Author), Golzio, Christelle (Author), Erdin, Serkan (Author), Blumenthal, Ian (Author), Manavalan, Poornima (Author), Ragavendran, Ashok (Author), Brand, Harrison (Author), Lucente, Diane (Author), Miles, Judith (Author), Sheridan, Steven D. (Author), Stortchevoi, Alexei (Author), Kellis, Manolis (Contributor), Haggarty, Stephen J. (Author), Katsanis, Nicholas (Author), Gusella, James F. (Author), Talkowski, Michael E. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2015-04-28T20:33:25Z.
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