Testing the Substrate-Envelope Hypothesis with Designed Pairs of Compounds

Testing the Substrate-Envelope Hypothesis with Designed Pairs of Compounds

Acquired resistance to therapeutic agents is a significant barrier to the development of clinically effective treatments for diseases in which evolution occurs on clinical time scales, frequently arising from target mutations. We previously reported a general strategy to design effective inhibitors...

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Main Authors: Shen, Yang (Contributor), Altman, Michael D. (Contributor), Ali, Akbar (Author), Nalam, Madhavi N. L. (Author), Cao, Hong (Author), Rana, Tariq M. (Author), Schiffer, Celia A. (Author), Tidor, Bruce (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2015-04-24T19:06:38Z.
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