Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition

Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition

Characterizing changes in protein-protein interactions associated with sequence variants (e.g., disease-associated mutations or splice forms) or following exposure to drugs, growth factors or hormones is critical to understanding how protein complexes are built, localized and regulated. Affinity pur...

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Main Authors: Lambert, Jean-Philippe (Author), Ivosev, Gordana (Author), Couzens, Amber L (Author), Larsen, Brett (Author), Taipale, Mikko (Author), Lin, Zhen-Yuan (Author), Zhong, Quan (Author), Lindquist, Susan (Contributor), Vidal, Marc (Author), Aebersold, Ruedi (Author), Pawson, Tony (Author), Bonner, Ron (Author), Tate, Stephen (Author), Gingras, Anne-Claude (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2015-04-21T18:50:58Z.
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