SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging
SIRT1 is a NAD[superscript +]-dependent protein deacetylase that governs many physiological pathways, including circadian rhythm in peripheral tissues. Here, we show that SIRT1 in the brain governs central circadian control by activating the transcription of the two major circadian regulators, BMAL1...
| Main Authors: | , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier,
2015-04-07T17:11:58Z.
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| Subjects: | |
| Online Access: | Get fulltext |