Molecular and Mesoscale Mechanisms of Osteogenesis Imperfecta Disease in Collagen Fibrils

Molecular and Mesoscale Mechanisms of Osteogenesis Imperfecta Disease in Collagen Fibrils

Osteogenesis imperfecta (OI) is a genetic disorder in collagen characterized by mechanically weakened tendon, fragile bones, skeletal deformities, and in severe cases, prenatal death. Although many studies have attempted to associate specific mutation types with phenotypic severity, the molecular an...

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Bibliographic Details
Main Authors: Gautieri, Alfonso (Contributor), Vesentini, Simone (Author), Redaelli, Alberto (Author), Uzel, Sebastien Guy Marcel (Author), Buehler, Markus J (Author)
Other Authors: Massachusetts Institute of Technology. Center for Computational Engineering (Contributor), Massachusetts Institute of Technology. Department of Civil and Environmental Engineering (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor), Massachusetts Institute of Technology. Laboratory for Atomistic and Molecular Mechanics (Contributor), Uzel, Sebastien GM (Contributor), Buehler, Markus J. (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2015-04-02T19:23:06Z.
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