The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming

The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming

Reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) entails a mesenchymal to epithelial transition (MET). While attempting to dissect the mechanism of MET during reprogramming, we observed that knockdown (KD) of the epithelial-to-mesenchymal transition (EMT) factor SNAI1 (SNAIL) p...

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Bibliographic Details
Main Authors: Unternaehrer, Juli J (Author), Zhao, Rui (Author), Kim, Kitai (Author), Cesana, Marcella (Author), Powers, John T (Author), Ratanasirintrawoot, Sutheera (Author), Onder, Tamer T. (Author), Shibue, Tsukasa (Contributor), Weinberg, Robert A (Author), Daley, George Q. (Author), Weinberg, Robert A (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Ludwig Center for Molecular Oncology (Massachusetts Institute of Technology) (Contributor), Weinberg, Robert A. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-04-02T17:08:06Z.
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