Reprogramming Factor Stoichiometry Influences the Epigenetic State and Biological Properties of Induced Pluripotent Stem Cells

Reprogramming Factor Stoichiometry Influences the Epigenetic State and Biological Properties of Induced Pluripotent Stem Cells

We compared two genetically highly defined transgenic systems to identify parameters affecting reprogramming of somatic cells to a pluripotent state. Our results demonstrate that the level and stoichiometry of reprogramming factors during the reprogramming process strongly influence the resulting pl...

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Bibliographic Details
Main Authors: Carey, Bryce W. (Contributor), Markoulaki, Styliani (Author), Hanna, Jacob (Author), Faddah, Dina A. (Contributor), Buganim, Yosef (Author), Kim, Jongpil (Author), Ganz, Kibibi (Author), Steine, Eveline J (Author), Cassady, John P. (Contributor), Creyghton, Menno P. (Author), Welstead, G. Grant (Author), Gao, Qing (Author), Jaenisch, Rudolf (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-03-04T19:02:11Z.
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