Function of the Diiron Cluster of Escherichia coli Class Ia Ribonucleotide Reductase in Proton-Coupled Electron Transfer

Function of the Diiron Cluster of Escherichia coli Class Ia Ribonucleotide Reductase in Proton-Coupled Electron Transfer

The class Ia ribonucleotide reductase (RNR) from Escherichia coli employs a free-radical mechanism, which involves bidirectional translocation of a radical equivalent or "hole" over a distance of ~35 Å from the stable diferric/tyrosyl-radical (Y[subscript 122]•) cofactor in the β subunit...

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Main Authors: Wörsdörfer, Bigna (Author), Conner, Denise A. (Author), Yokoyama, Kenichi (Contributor), Livada, Jovan (Author), Jiang, Wei (Author), Silakov, Alexey (Author), Stubbe, JoAnne (Contributor), Bollinger, J. Martin (Author), Krebs, Carsten (Author), Seyedsayamdost, Mohammad R. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Seyedsayamdost, Mohammad (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2015-02-26T18:08:31Z.
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