Synthesis and Anticancer Activity of All Known (−)-Agelastatin Alkaloids

Synthesis and Anticancer Activity of All Known (−)-Agelastatin Alkaloids

The full details of our enantioselective total syntheses of (−)-agelastatins A-F (1-6), the evolution of a new methodology for synthesis of substituted azaheterocycles, and the first side-by-side evaluation of all known (−)-agelastatin alkaloids against nine human cancer cell lines are described. Ou...

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Main Authors: Han, Sunkyu (Contributor), Siegel, Dustin S. (Contributor), Morrison, Karen C. (Author), Hergenrother, Paul J. (Author), Movassaghi, Mohammad (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2015-02-25T16:19:32Z.
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