Loss of α-catenin elicits a cholestatic response and impairs liver regeneration

Loss of α-catenin elicits a cholestatic response and impairs liver regeneration

The liver is unique in its capacity to regenerate after injury, during which hepatocytes actively divide and establish cell-cell contacts through cell adhesion complexes. Here, we demonstrate that the loss of α-catenin, a well-established adhesion component, dramatically disrupts liver regeneration....

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Main Authors: Herr, Keira Joann (Author), Tsang, Ying-hung Nicole (Author), Ong, Joanne Wei En (Author), Li, Qiushi (Author), Yap, Lai Lai (Author), Yu, Weimiao (Author), Yin, Hao (Contributor), Dahlman, James E. (Contributor), Chan, Yee Gek (Author), Bay, Boon Huat (Author), Singaraja, Roshni (Author), Kotelianski, Victor E. (Author), Viasnoff, Virgile (Author), Thiery, Jean Paul (Author), Bogorad, Roman (Contributor), Anderson, Daniel Griffith (Contributor)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-12-31T20:19:49Z.
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