Tet1 Is Dispensable for Maintaining Pluripotency and Its Loss Is Compatible with Embryonic and Postnatal Development

Tet1 Is Dispensable for Maintaining Pluripotency and Its Loss Is Compatible with Embryonic and Postnatal Development

The Tet family of enzymes (Tet1/2/3) converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Mouse embryonic stem cells (mESCs) highly express Tet1 and have an elevated level of 5hmC. Tet1 has been implicated in ESC maintenance and lineage specification in vitro but its precise function i...

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Bibliographic Details
Main Authors: Dawlaty, Meelad M. (Author), Ganz, Kibibi (Author), Powell, Benjamin E (Author), Hu, Yueh-Chiang (Author), Markoulaki, Styliani (Author), Cheng, Albert W. (Contributor), Gao, Qing (Author), Kim, Jongpil (Author), Choi, Sang-Woon (Author), Jaenisch, Rudolf (Contributor), Page, David C (Author)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Page, David C. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-12-30T18:28:14Z.
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