Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism

Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism

Succinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex involved in both the electron transport chain and the citric acid cycle. SDH mutations resulting in enzymatic dysfunction have been found to be a predisposing factor in various hereditary cancers. Therefore, SDH has been impli...

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Main Authors: Aspuria, Paul-Joseph P. (Author), Lunt, Sophia Yunkyungkwon (Contributor), Väremo, Leif (Author), Vergnes, Laurent (Author), Gozo, Maricel (Author), Beach, Jessica A (Author), Salumbides, Brenda (Author), Reue, Karen (Author), Wiedemeyer, W. R. (Author), Nielsen, Jens Kromann (Author), Karlan, Beth Y. (Author), Orsulic, Sandra (Author)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: BioMed Central Ltd., 2014-12-24T16:24:27Z.
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