End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug prod...

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Bibliographic Details
Main Authors: Mascia, Salvatore (Contributor), Heider, Patrick L. (Contributor), Zhang, Haitao (Contributor), Lakerveld, Richard (Contributor), Benyahia, Brahim (Contributor), Barton, Paul I. (Contributor), Braatz, Richard D. (Contributor), Cooney, Charles L. (Contributor), Evans, James M. B. (Contributor), Jamison, Timothy F. (Contributor), Jensen, Klavs F. (Contributor), Myerson, Allan S. (Contributor), Trout, Bernhardt L. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2014-12-23T14:17:13Z.
Subjects:
Online Access:Get fulltext
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100 1 0 |a Mascia, Salvatore  |e author 
100 1 0 |a Massachusetts Institute of Technology. Department of Chemical Engineering  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Department of Chemistry  |e contributor 
100 1 0 |a Trout, Bernhardt L.  |e contributor 
100 1 0 |a Mascia, Salvatore  |e contributor 
100 1 0 |a Heider, Patrick L.  |e contributor 
100 1 0 |a Zhang, Haitao  |e contributor 
100 1 0 |a Lakerveld, Richard  |e contributor 
100 1 0 |a Benyahia, Brahim  |e contributor 
100 1 0 |a Barton, Paul I.  |e contributor 
100 1 0 |a Braatz, Richard D.  |e contributor 
100 1 0 |a Cooney, Charles L.  |e contributor 
100 1 0 |a Evans, James M. B.  |e contributor 
100 1 0 |a Jamison, Timothy F.  |e contributor 
100 1 0 |a Jensen, Klavs F.  |e contributor 
100 1 0 |a Myerson, Allan S.  |e contributor 
100 1 0 |a Trout, Bernhardt L.  |e contributor 
700 1 0 |a Heider, Patrick L.  |e author 
700 1 0 |a Zhang, Haitao  |e author 
700 1 0 |a Lakerveld, Richard  |e author 
700 1 0 |a Benyahia, Brahim  |e author 
700 1 0 |a Barton, Paul I.  |e author 
700 1 0 |a Braatz, Richard D.  |e author 
700 1 0 |a Cooney, Charles L.  |e author 
700 1 0 |a Evans, James M. B.  |e author 
700 1 0 |a Jamison, Timothy F.  |e author 
700 1 0 |a Jensen, Klavs F.  |e author 
700 1 0 |a Myerson, Allan S.  |e author 
700 1 0 |a Trout, Bernhardt L.  |e author 
245 0 0 |a End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation 
260 |b Wiley Blackwell,   |c 2014-12-23T14:17:13Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/92450 
520 |a A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system. 
520 |a Novartis (Firm) 
546 |a en_US 
655 7 |a Article 
773 |t Angewandte Chemie International Edition