C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability

C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability

DNA replication and its connection to M phase restraint are studied extensively at the level of single cells but rarely in the context of a developing animal. C. elegans lin-6 mutants lack DNA synthesis in postembryonic somatic cell lineages, while entry into mitosis continues. These mutants grow sl...

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Bibliographic Details
Main Authors: Korzelius, Jerome (Author), The, Inge (Author), Ruijtenberg, Suzan (Author), Portegijs, Vincent (Author), Xu, Huihong (Author), van den Heuvel, Sander (Author), Horvitz, Howard Robert (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Horvitz, H. Robert (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-12-16T18:06:39Z.
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