Optimality in the Development of Intestinal Crypts

Optimality in the Development of Intestinal Crypts

Intestinal crypts in mammals are comprised of long-lived stem cells and shorter-lived progenies. These two populations are maintained in specific proportions during adult life. Here, we investigate the design principles governing the dynamics of these proportions during crypt morphogenesis. Using op...

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Bibliographic Details
Main Authors: Itzkovitz, Shaul Shalev (Contributor), Blat, Irene C. (Contributor), Clevers, Hans (Author), van Oudenaarden, Alexander (Author), Jacks, Tyler E. (Contributor), van Oudenaarden, Alexander (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-12-10T16:12:42Z.
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