Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability

Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability

Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAE...

Full description

Bibliographic Details
Main Authors: Eltoukhy, Ahmed A. (Contributor), Chen, Delai (Contributor), Alabi, Christopher A. (Author), Anderson, Daniel Griffith (Contributor), Langer, Robert S (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Langer, Robert (Contributor)
Format: Article
Language:English
Published: Wiley-VCH Verlag GmbH & Co., 2014-10-30T19:05:13Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items