Calcium Causes a Conformational Change in Lamin A Tail Domain that Promotes Farnesyl-Mediated Membrane Association

Calcium Causes a Conformational Change in Lamin A Tail Domain that Promotes Farnesyl-Mediated Membrane Association

Lamin proteins contribute to nuclear structure and function, primarily at the inner nuclear membrane. The posttranslational processing pathway of lamin A includes farnesylation of the C-terminus, likely to increase membrane association, and subsequent proteolytic cleavage of the C-terminus. Hutchins...

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Bibliographic Details
Main Authors: Kalinowski, Agnieszka (Author), Qin, Zhao (Contributor), Coffey, Kelli (Author), Kodali, Ravi (Author), Buehler, Markus J. (Contributor), Dahl, Kris Noel (Author), Losche, Mathias (Author)
Other Authors: Massachusetts Institute of Technology. Department of Civil and Environmental Engineering (Contributor), Massachusetts Institute of Technology. School of Engineering (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-09-05T18:53:57Z.
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