MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice

Commensal bacterial sensing by Toll-like receptors is critical for maintaining intestinal homeostasis, but can lead to colitis in the absence of interleukin-10. Although Toll-like receptors are expressed in multiple cell types in the colon, the cell type(s) responsible for the development of colitis...

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Main Authors: Hoshi, Namiko (Author), Schenten, Dominik (Author), Nish, Simone A. (Author), Walther, Zenta (Author), Gagliani, Nicola (Author), Flavell, Richard A. (Author), Reizis, Boris (Author), Shen, Zeli (Contributor), Fox, James G. (Contributor), Iwasaki, Akiko (Author), Medzhitov, Ruslan (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Division of Comparative Medicine (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-09-03T14:37:29Z.
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