Structural Determinants for Naturally Evolving H5N1 Hemagglutinin to Switch Its Receptor Specificity

Structural Determinants for Naturally Evolving H5N1 Hemagglutinin to Switch Its Receptor Specificity

Of the factors governing human-to-human transmission of the highly pathogenic avian-adapted H5N1 virus, the most critical is the acquisition of mutations on the viral hemagglutinin (HA) to "quantitatively switch" its binding from avian to human glycan receptors. Here, we describe a structu...

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Bibliographic Details
Main Authors: Tharakaraman, Kannan (Contributor), Raman, Rahul (Contributor), Viswanathan, Karthik (Contributor), Stebbins, Nathan W (Author), Jayaraman, Akila (Contributor), Krishnan, Arvind (Contributor), Sasisekharan, Ram (Contributor), Stebbins, Nathan W. (Contributor), Sasisekharan, Viswanathan (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sasisekharan, V. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-08-26T14:47:14Z.
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