A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α

A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α

Emerging evidence points to aberrant regulation of translation as a driver of cell transformation in cancer. Given the direct control of translation by tRNA modifications, tRNA modifying enzymes may function as regulators of cancer progression. Here, we show that a tRNA methyltransferase 9‐like (hTR...

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Main Authors: Begley, Ulrike (Author), Sosa, Maria Soledad (Author), Avivar-Valderas, Alvaro (Author), Patil, Ashish (Author), Endres, Lauren (Author), Estrada, Yeriel (Author), Chan, Tsz Yan Clement (Contributor), Su, Dan (Contributor), Dedon, Peter C. (Contributor), Aguirre-Ghiso, Julio A. (Author), Begley, Thomas J. (Author)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2014-07-08T15:26:27Z.
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