Tissue-specific gene silencing monitored in circulating RNA
Pharmacologic target gene modulation is the primary objective for RNA antagonist strategies and gene therapy. Here we show that mRNAs encoding tissue-specific gene transcripts can be detected in biological fluids and that RNAi-mediated target gene silencing in the liver and brain results in quantita...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Cold Spring Harbor Laboratory Press,
2014-05-29T15:00:56Z.
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| Subjects: | |
| Online Access: | Get fulltext |