Creating a False Memory in the Hippocampus

Creating a False Memory in the Hippocampus

Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram-bearing cells in the hippocampus. Dentate gyrus (DG) or CA1 neurons activated by exposure to a particular context were labeled with channelrhodopsin-2. These neurons were later optically react...

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Main Authors: Ramirez Moreno, Steve (Contributor), Liu, Xu (Contributor), Lin, Pei-Ann (Contributor), Suh, Junghyup (Contributor), Ryan, Tomas John (Contributor), Redondo, Roger L. (Contributor), Tonegawa, Susumu (Contributor), Pignatelli di Spinazzola, Michele (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor), RIKEN-MIT Center for Neural Circuit Genetics (Contributor), Pignatelli di Spinazzola, Mich (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2014-03-28T18:14:02Z.
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