The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome

The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome

Many large noncoding RNAs (lncRNAs) regulate chromatin, but the mechanisms by which they localize to genomic targets remain unexplored. We investigated the localization mechanisms of the Xist lncRNA during X-chromosome inactivation (XCI), a paradigm of lncRNA-mediated chromatin regulation. During th...

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Main Authors: Engreitz, Jesse Michael (Contributor), Pandya-Jones, Amy (Author), McDonel, Patrick (Author), Shishkin, Alexander (Author), Sirokman, Klara (Author), Surka, Christine (Author), Kadri, Sabah (Author), Xing, Jeffrey (Author), Goren, Alon (Author), Plath, Kathrin (Author), Guttman, Mitchell (Author), Lander, Eric Steven (Author)
Other Authors: Whitaker College of Health Sciences and Technology (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Lander, Eric S. (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2014-03-10T16:25:57Z.
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