Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins

Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins

Cells genetically deficient in sphingomyelin synthase-1 (SGMS1) or blocked in their synthesis pharmacologically through exposure to a serine palmitoyltransferase inhibitor (myriocin) show strongly reduced surface display of influenza virus glycoproteins hemagglutinin (HA) and neuraminidase (NA). The...

Full description

Bibliographic Details
Main Authors: Ploegh, Hidde (Contributor), Tafesse, Fikadu G. (Author), Sanyal, Sumana (Author), Ashour, Joseph (Author), Guimaraes, Carla P. (Author), Hermansson, Martin (Author), Somerharju, Pentti (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2014-02-14T15:19:03Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items