Melanoma genome sequencing reveals frequent PREX2 mutations

Melanoma genome sequencing reveals frequent PREX2 mutations

Melanoma is notable for its metastatic propensity, lethality in the advanced setting and association with ultraviolet exposure early in life. To obtain a comprehensive genomic view of melanoma in humans, we sequenced the genomes of 25 metastatic melanomas and matched germline DNA. A wide range of po...

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Main Authors: Berger, Michael F. (Author), Hodis, Eran (Author), Heffernan, Timothy P. (Author), Deribe, Yonathan Lissanu (Author), Lawrence, Michael S. (Author), Protopopov, Alexei (Author), Ivanova, Elena (Author), Watson, Ian R. (Author), Nickerson, Elizabeth (Author), Ghosh, Papia (Author), Zhang, Hailei (Author), Zeid, Rhamy (Author), Ren, Xiaojia (Author), Cibulskis, Kristian (Author), Sivachenko, Andrey Y. (Author), Wagle, Nikhil (Author), Sucker, Antje (Author), Sougnez, Carrie (Author), Onofrio, Robert (Author), Lander, Eric Steven (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Lander, Eric S. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-02-03T19:55:03Z.
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