In-silico and in-vitro elucidation of BH3 binding specificity towards Bcl-2
Interactions between Bcl-2-like proteins and BH3 domains play a key role in the regulation of apoptosis. Despite the overall structural similarity of their interaction with helical BH3 domains, Bcl-2-like proteins exhibit an intricate spectrum of binding specificities whose underlying basis is not w...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society (ACS),
2014-01-31T17:35:47Z.
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| Subjects: | |
| Online Access: | Get fulltext |