Targeting p35/Cdk5 Signalling via CIP-Peptide Promotes Angiogenesis in Hypoxia

Targeting p35/Cdk5 Signalling via CIP-Peptide Promotes Angiogenesis in Hypoxia

Cyclin-dependent kinase-5 (Cdk5) is over-expressed in both neurons and microvessels in hypoxic regions of stroke tissue and has a significant pathological role following hyper-phosphorylation leading to calpain-induced cell death. Here, we have identified a critical role of Cdk5 in cytoskeleton/foca...

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Main Authors: Bosutti, Alessandra (Author), Qi, Jie (Author), Pennucci, Roberta (Author), Bolton, David (Author), Matou, Sabine (Author), Ali, Kamela (Author), Tsai, Li-Huei (Contributor), Krupinski, Jerzy (Author), Petcu, Eugene B. (Author), Montaner, Joan (Author), Al Baradie, Raid (Author), Caccuri, Francesca (Author), Caruso, Arnaldo (Author), Alessandri, Giulio (Author), Kumar, Shant (Author), Rodriguez, Cristina (Author), Martinez-Gonzalez, Jose (Author), Slevin, Mark (Author)
Other Authors: Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2014-01-06T19:13:06Z.
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