Molecular Basis for Specific Regulation of Neuronal Kinesin-3 Motors by Doublecortin Family Proteins

Molecular Basis for Specific Regulation of Neuronal Kinesin-3 Motors by Doublecortin Family Proteins

Doublecortin (Dcx) defines a growing family of microtubule (MT)-associated proteins (MAPs) involved in neuronal migration and process outgrowth. We show that Dcx is essential for the function of Kif1a, a kinesin-3 motor protein that traffics synaptic vesicles. Neurons lacking Dcx and/or its structur...

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Main Authors: Liu, Judy S (Author), Schubert, Christian R (Author), Fu, Xiaoqin (Author), Fourniol, Franck J (Author), Jaiswal, Jyoti K (Author), Houdusse, Anne (Author), Stultz, Collin M (Author), Moores, Carolyn A (Author), Walsh, Christopher A (Author), Schubert, Christian R. (Contributor), Stultz, Collin M. (Contributor)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Research Laboratory of Electronics (Contributor)
Format: Article
Language:English
Published: Elsevier, 2013-11-18T16:06:49Z.
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