Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction

Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction

(S)-2-hydroxypropylphosphonate ((S)-2-HPP) epoxidase (HppE) is a mononuclear non-haem-iron-dependent enzyme1, 2, 3 responsible for the final step in the biosynthesis of the clinically useful antibiotic fosfomycin4. Enzymes of this class typically catalyse oxygenation reactions that proceed via the f...

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Bibliographic Details
Main Authors: Chang, Wei-chen (Author), Dey, Mishtu (Contributor), Liu, Pinghua (Author), Mansoorabadi, Steven O. (Author), Moon, Sung-Ju (Author), Zhao, Zongbao K. (Author), Liu, Hung-wen (Author), Drennan, Catherine L (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Drennan, Catherine L. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2013-11-07T17:27:24Z.
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