Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction

Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction

(S)-2-hydroxypropylphosphonate ((S)-2-HPP) epoxidase (HppE) is a mononuclear non-haem-iron-dependent enzyme1, 2, 3 responsible for the final step in the biosynthesis of the clinically useful antibiotic fosfomycin4. Enzymes of this class typically catalyse oxygenation reactions that proceed via the f...

Full description

Bibliographic Details
Main Authors: Chang, Wei-chen (Author), Dey, Mishtu (Contributor), Liu, Pinghua (Author), Mansoorabadi, Steven O. (Author), Moon, Sung-Ju (Author), Zhao, Zongbao K. (Author), Liu, Hung-wen (Author), Drennan, Catherine L (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Drennan, Catherine L. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2013-11-07T17:27:24Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items