Tangled Up in Knots: Structures of Inactivated Forms of E. coli Class Ia Ribonucleotide Reductase

Tangled Up in Knots: Structures of Inactivated Forms of E. coli Class Ia Ribonucleotide Reductase

Ribonucleotide reductases (RNRs) provide the precursors for DNA biosynthesis and repair and are successful targets for anticancer drugs such as clofarabine and gemcitabine. Recently, we reported that dATP inhibits E. coli class Ia RNR by driving formation of RNR subunits into α4β4 rings. Here, we pr...

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Bibliographic Details
Main Authors: Zimanyi, Christina Marie (Contributor), Ando, Nozomi (Contributor), Asturias, Francisco J. (Author), Stubbe, JoAnne (Contributor), Brignole, Edward J (Author), Drennan, Catherine L (Author)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Brignole, Edward J. (Contributor), Drennan, Catherine L. (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2013-11-06T20:36:53Z.
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