Impact of deleterious passenger mutations on cancer progression

Impact of deleterious passenger mutations on cancer progression

Cancer progression is driven by the accumulation of a small number of genetic alterations. However, these few driver alterations reside in a cancer genome alongside tens of thousands of additional mutations termed passengers. Passengers are widely believed to have no role in cancer, yet many passeng...

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Bibliographic Details
Main Authors: Korolev, Kirill Sergeevich (Contributor), Sunyaev, Shamil R. (Contributor), McFarland, Christopher D. (Author), Kryukov, Gregory V. (Author), Mirny, Leonid A (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Massachusetts Institute of Technology. School of Engineering (Contributor), Mirny, Leonid A. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2013-09-11T12:10:53Z.
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