SH3 interactome conserves general function over specific form

Src homology 3 (SH3) domains bind peptides to mediate protein-protein interactions that assemble and regulate dynamic biological processes. We surveyed the repertoire of SH3 binding specificity using peptide phage display in a metazoan, the worm Caenorhabditis elegans, and discovered that it structu...

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Bibliographic Details
Main Authors: Xin, Xiaofeng (Contributor), Gfeller, David (Author), Cheng, Jackie (Author), Tonikian, Raffi (Author), Sun, Lin (Author), Guo, Ailan (Author), Lopez, Lianet (Author), Pavlenco, Alevtina (Author), Akintobi, Adenrele (Author), Zhang, Yingnan (Author), Currell, Bridget (Author), Seshagiri, Somasekar (Author), Hao, Tong (Author), Yang, Xinping (Author), Shen, Yun A. (Author), Salehi-Ashtiani, Kourosh (Author), Li, Jingjing (Author), Cheng, Aaron T. (Author), Bouamalay, Dryden (Author), Lugari, Adrien (Author), Hill, David E. (Author), Grimes, Mark L. (Author), Drubin, David G. (Author), Grant, Barth D. (Author), Vidal, Marc (Author), Boone, Charles W. (Author), Sidhu, Sachdev S. (Author), Bader, Gary D. (Author), Rual, Jean-Francois (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2013-09-06T13:42:39Z.
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