Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

Show other versions (1)

Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder that manifests with personality changes, movement disorders, and cognitive decline. It is caused by a CAG repeat expansion in exon 1 of the HTT gene that translates to a polyglutamine tract in the huntingtin p...

Full description

Bibliographic Details
Main Authors: Sathasivam, Kirupa (Author), Neueder, Andreas (Author), Landles, Christian (Author), Benjamin, Agnesska C. (Author), Bondulich, Marie K. (Author), Amith, Donna L. (Author), Faull, Richard L. M. (Author), Roos, Raymund A. C. (Author), Howland, David (Author), Detloff, Peter J. (Author), Bates, Gillian P. (Author), Housman, David E (Author), Wasylenko, Theresa Anne (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Gipson, Theresa Anne (Contributor), Housman, David E. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2013-08-08T18:48:24Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items