Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1

Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1

Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues. Although base excision repair (BER) is essential in repairing DNA alkylation damage, under certain conditions, initiation o...

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Bibliographic Details
Main Authors: Calvo, Jennifer A. (Contributor), Moroski-Erkul, Catherine A. (Contributor), Lake, Annabelle (Contributor), Eichinger, Lindsey Wood (Contributor), Shah, Dharini (Contributor), Jhun, Iny (Contributor), Limsirichai, Prajit (Contributor), Bronson, Roderick T. (Author), Christiani, David C. (Author), Meira, Lisiane B. (Contributor), Samson, Leona D. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2013-07-01T16:46:59Z.
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