Endogenously produced nitric oxide mitigates sensitivity of melanoma cells to cisplatin

Endogenously produced nitric oxide mitigates sensitivity of melanoma cells to cisplatin

Melanoma patients experience inferior survival after biochemotherapy when their tumors contain numerous cells expressing the inducible isoform of NO synthase (iNOS) and elevated levels of nitrotyrosine, a product derived from NO. Although several lines of evidence suggest that NO promotes tumor grow...

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Bibliographic Details
Main Authors: Godoy, Luiz Claudio (Contributor), Anderson, Chase T. (Contributor), Chowdhury, Rajdeep (Contributor), Trudel, Laura J. (Contributor), Wogan, Gerald N. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2013-06-27T18:54:36Z.
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