Rational, combinatorial, and genomic approaches for engineering L-tyrosine production in Escherichia coli
Although microbial metabolic engineering has traditionally relied on rational and knowledge-driven techniques, significant improvements in strain performance can be further obtained through the use of combinatorial approaches exploiting phenotypic diversification and screening. Here, we demonstrate...
Main Authors: | Santos, Christine Nicole S. (Contributor), Xiao, Wenhai (Contributor), Stephanopoulos, Gregory (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor) |
Format: | Article |
Language: | English |
Published: |
National Academy of Sciences (U.S.),
2013-03-07T20:55:41Z.
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Subjects: | |
Online Access: | Get fulltext |
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