Rational, combinatorial, and genomic approaches for engineering L-tyrosine production in Escherichia coli

Although microbial metabolic engineering has traditionally relied on rational and knowledge-driven techniques, significant improvements in strain performance can be further obtained through the use of combinatorial approaches exploiting phenotypic diversification and screening. Here, we demonstrate...

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Bibliographic Details
Main Authors: Santos, Christine Nicole S. (Contributor), Xiao, Wenhai (Contributor), Stephanopoulos, Gregory (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2013-03-07T20:55:41Z.
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