Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins

Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins

Selective translation of survival proteins is an important facet of the cellular stress response. We recently demonstrated that this translational control involves a stress-specific reprogramming of modified ribonucleosides in tRNA. Here we report the discovery of a step-wise translational control m...

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Main Authors: Chan, Tsz Yan Clement (Contributor), Pang, Yan Ling Joy (Contributor), Deng, Wenjun (Contributor), Indrakanti, Ramesh Babu (Contributor), Dyavaiah, Madhu (Author), Begley, Thomas J. (Author), Dedon, Peter C. (Contributor)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Dedon, Peter (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2013-02-11T21:04:53Z.
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