Differential Requirement for CD70 and CD80/CD86 in Dendritic Cellmediated Activation of Tumor Tolerized CD8 T Cells

Differential Requirement for CD70 and CD80/CD86 in Dendritic Cellmediated Activation of Tumor Tolerized CD8 T Cells

A major obstacle to efficacious T cell-based cancer immunotherapy is the tolerizing-tumor microenvironment that rapidly inactivates tumor-infiltrating lymphocytes. In an autochthonous model of prostate cancer, we have previously shown that intratumoral injection of Ag-loaded dendritic cells (DCs) de...

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Bibliographic Details
Main Authors: Barnkob, Mike Stein (Contributor), Bai, Ailin (Contributor), Higham, Eileen M. (Contributor), Wittrup, Karl Dane (Contributor), Chen, Jianzhu (Contributor), Bak, Peter (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Bak, S. Peter G. (Contributor)
Format: Article
Language:English
Published: American Association of Immunologists, 2012-11-07T17:32:15Z.
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